高国粉

教授、硕士生导师

联系电话：0311-80787587；15631123003

电子邮件：gaoguofen@hebtu.edu.cn

学科专业：生理学、神经生理学方向

学习经历：

2008--2013年， The Catholic University of America (美国)，细胞与微生物学，博士。导师：Venigalla B. Rao.

2006--2008年，吉林大学 yl6809永利官网，微生物与生化药学，硕士。导师：滕利荣。

2002--2006年，吉林大学 yl6809永利官网，制药工程，本科。

主要教学科研工作：

教学工作：属于yl6809永利官网解剖生理学教研室，承担本科生课程包括《人体及动物生理学》、《组织学与解剖学》、；研究生课程包括《铁代谢分子生物学大实验》、《生理学专业英语》。

科研方向：(1) 神经退行性疾病的发病机制及治疗策略研究；(2) 铁代谢相关分子调节脑铁平衡的机制研究。

所获荣誉：

河北省第三批“青年拔尖人才”（2018年）；

河北师范大学院处级先进工作者（2020、2022、2023年）；

河北师范大学师德师风考核优秀教师（2020、2022、2023、2024年）；

河北师范大学本科教学质量优秀教师（2016、2018、2019、2021年）；

yl6809永利官网“十佳魅力教师”（2023年）

承担的主要科研项目：

1. 河北省自然科学基金-杰出青年项目，2023-2026，主持人。

2. 国家自然科学基金-面上项目，2022-2025，主持人。

3. 河北省教育厅基金-重点项目，2021-2023，主持人。

4. 河北省自然科学基金-面上项目，2019-2022，主持人。

5. 河北省教育厅高等学校青年拔尖人才项目，2017-2019，主持人。

6. 国家自然科学基金-青年项目，2015-2017，主持人。

7. 河北省自然科学基金-青年项目，2015-2017，主持人。

8. 教育部留学归国人员科研启动基金，第48批，2014-2016，主持人。

代表性论文：

(1) Yiqian Ding, Shanshan Yao, Shuxin Guo, Wei Meng, Jie Li, Fudi Wang, Jianhua Zhang, Yan-Zhong Chang*, Guofen Gao*. Ferroportin 1 depletion in neural stem cells promotes hippocampal neurogenesis and cognitive function in mice. Pharmacological Research. 2025, 216:107778.

(2) Xue Bai, Bing Wang, Yiduo Cui, Siqi Tian, Yi Zhang, Linhao You, Yan-Zhong Chang*, Guofen Gao*. Hepcidin deficiency impairs hippocampal neurogenesis and mediates brain atrophy and memory decline in mice. Journal of Neuroinflammation. 2024, 21(1):15

(3) Shiyang Chang, Peina Wang, Yingying Han, Qiang Ma, Zeyuan Liu, Suijuan Zhong, Yufeng Lu, Ruiguo Chen, Le Sun, Qian Wu, Guofen Gao*, Xiaoqun Wang*, Yan-Zhong Chang*. Ferrodifferentiation regulates neurodevelopment via ROS generation. Science China Life Sciences. 2023, 66(8): 1841-1857

(4) Yi Zhang, Xiaoqin Gao, Xue Bai, Shanshan Yao, Yan-Zhong Chang*, Guofen Gao*. The emerging role of furin in neurodegenerative and neuropsychiatric diseases. Translational Neurodegeneration. 2022, 11: 39

(5) Linhao You, Pan-Pan Yu, Tianyu Dong, Wenhuan Guo, Shiyang Chang, Bingjie Zheng, Yunzhe Ci, Fudi Wang, Peng Yu, Guofen Gao*, Yan-Zhong Chang*. Astrocyte-derived hepcidin controls iron traffic at the blood-brain-barrier via regulating ferroportin 1 of microvascular endothelial cells. Cell Death and Disease. 2022, 13: 667

(6) Jie Li, Yiqian Ding, Jianhua Zhang, Yating Zhang, Yiduo Cui, Yi Zhang, Shiyang Chang*, Yan-Zhong Chang*, Guofen Gao*. Iron overload suppresses hippocampal neurogenesis in adult mice: Implication for iron dysregulation-linked neurological diseases. CNS Neuroscience & Therapeutics. 2024, 30(2): e14394

(7) Guofen Gao, Linhao You, Jianhua Zhang, Yan-Zhong Chang*, Peng Yu*. Brain Iron Metabolism, Redox Balance and Neurological Diseases. Antioxidants, 2023, 12, 1289

(8) Yating Zhang, Xue Bai, Yi Zhang, Shanshan Yao, Yiduo Cui, Lin-Hao You, Peng Yu*, Yan-Zhong Chang*, Guofen Gao*. Hippocampal Iron Accumulation Impairs Synapses and Memory via Suppressing Furin Expression and Downregulating BDNF Maturation. Molecular Neurobiology. 2022, 59: 5574-5590

(9) Kang Han, Xiaofang Jin, Xin Guo, Guoli Cao, Siyu Tian, Yiming Song, Yuanyuan Zuo, Peng Yu, Guofen Gao*, Yan-Zhong Chang*. Nrf2 knockout altered brain iron deposition and mitigated age-related motor dysfunction in aging mice. Free Radical Biology and Medicine. 2021, 162: 592-602

(10) Yong Xu, Yating Zhang, Jian-Hua Zhang, Kang Han, Xinwei Zhang, Xue Bai, Lin-Hao You, Peng Yu, Zhenhua Shi, Yan-Zhong Chang*, Guofen Gao*. Astrocyte hepcidin ameliorates neuronal loss through attenuating brain iron deposition and oxidative stress in APP/PS1 mice. Free Radical Biology and Medicine. 2020, 158: 84-95

(11) Xinwei Zhang, Yu-Jing Gou, Yating Zhang, Jie Li, Kang Han, Yong Xu, Haiyan Li, Lin-Hao You, Peng Yu, Yan-Zhong Chang*, Guofen Gao*. Hepcidin overexpression in astrocytes alters brain iron metabolism and protects against amyloid-β induced brain damage in mice. Cell Death Discovery. 2020, 6: 113

(12) Zhenzhen Liu, Kang Han, Xuege Huo, Bingqi Yan, Mohan Gao, Xin Lv, Peng Yu, Guofen Gao*, Yan-Zhong Chang*. Nrf2 knockout dysregulates iron metabolism and increases the hemolysis through ROS in aging mice. Life Sciences. 2020, 255: 117838

(13) Lan Wang, Xiaopeng Liu, Lin-Hao You, Yun-Zhe Ci, Shiyang Chang, Peng Yu, Guofen Gao*, Yan-Zhong Chang*. Hepcidin and iron regulatory proteins coordinately regulate ferroportin 1 expression in the brain of mice. Journal of Cellular Physiology. 2019, 234: 7600-7607

(14) Guofen Gao*, Jie Li, Yating Zhang, Yan-Zhong Chang*. Cellular Iron Metabolism and Regulation. Advances in Experimental Medicine and Biology. 2019, 117321-32

(15) Guofen Gao, Nan Zhang, Yue-Qi Wang, Qiong Wu, Peng Yu, Zhen-Hua Shi, Xiang-Lin Duan, Bao-Lu Zhao, Wen-Shuang Wu, Yan-Zhong Chang*. Mitochondrial ferritin protects hydrogen peroxide-induced neuronal cell damage. Aging & Disease. 2017, 8(4): 458-470.